Johnson, S. R. Premenstrual syndrome therapy. View abstract. The etiopathogenesis of premenstrual syndrome as a consequence of altered blood rheology: a new hypothesis. Interactions between essential fatty acids and steroid hormones. Lancet 2-25-1995;345(8948):520. Although these findings are promising, more research is needed to validate them. View abstract. 1990;586:288-294. Prostagland Leukotrienes Med 1982;8:273-285. CONDITIONS OF USE AND IMPORTANT INFORMATION: J Pediatr 2008;152:140, 140.e1. Drugs Exp Clin Res 1988;14:291-7. Evening Primrose Oil Side Effects. A hormonal disorder that causes enlarged ovaries with cysts (. Rose DP, Connolly JM, Liu XH. any of the products or services that are advertised on the web site. A double-blind, randomized, placebo-controlled clinical trial. View abstract. LIVESTRONG is a registered trademark of the LIVESTRONG Foundation. View abstract. View abstract. Dietary supplement interactions with antiretrovirals: a systematic review. 2001;185(1):227-235. The lipids that matter from infant nutrition to insulin resistance. Warren G, McKendrick M, Peet M. The role of essential fatty acids in chronic fatigue syndrome. Journal of Dermatological Treatment 1993;4:33-36. Yoon, S., Lee, J., and Lee, S. The therapeutic effect of evening primrose oil in atopic dermatitis patients with dry scaly skin lesions is associated with the normalization of serum gamma-interferon levels. Skogh, M. Atopic eczema unresponsive to evening primrose oil (linoleic and gamma- linolenic acids). ), allergies, pre-existing diseases, and current health conditions (e.g. It can help minimize breast pain. Wedig KE, Whitsett JA. Prostaglandins Leukot Essent Fatty Acids 1989;37(3):145-147. Ring, J. and Kleinheinz, A. Phytother Res 2012;26:265-272. Abnormalities in plasma essential fatty acid levels in women with premenstrual syndrome and nonmalignant breast disease. advertisements are served by third party advertising companies. View abstract. Prostaglandins Leukot Essent Fatty Acids 1993;49:691-4. Farzaneh F, Fatehi S, Sohrabi MR, Alizadeh K. The effect of oral evening primrose oil on menopausal hot flashes: a randomized clinical trial. Lovell CR, Burton JL, and Horrobin DF. Clin Exp Hypertens B 1983;2:247-54. 2008;22(3):171-174. Oral omega-6 essential fatty acid treatment in contact lens associated dry eye. Am Fam.Physician 12-15-2009;80(12):1405-1408. Her mission is to help people live healthier lives by making smarter food choices and staying active. Johnson, M., Ostlund, S., Fransson, G., Kadesjo, B., and Gillberg, C. Omega-3/omega-6 fatty acids for attention deficit hyperactivity disorder: a randomized placebo-controlled trial in children and adolescents. Copyright Policy Rezapour-Firouzi S, Arefhosseini SR, Mehdi F, et al. High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia). Collins A, Cerin A, Coleman G, and Landgren BM. Acta Derm Venereol Suppl (Stockh) 1985;114:143-145. Warnings. View abstract. View abstract. Larsson B, Jonasson A, and Fianu S. Evening primrose oil in the treatment of premenstrual syndrome. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Med Hypotheses 2000;54(1):72-74. Am J Obstet Gynecol 2002;187:1389-94.. View abstract. Balci FL, Uras C, Feldman S. Clinical factors affecting the therapeutic efficacy of evening primrose oil on mastalgia. J Educ Health Promot. The Proceedings of the 4th International Benign Breast Symposium. View abstract. Gateley, C. A., Maddox, P. R., Mansel, R. E., and Hughes, L. E. Mastalgia refractory to drug treatment. View abstract. Allergo J 1998;7(4):213-216. Aragona, P., Bucolo, C., Spinella, R., Giuffrida, S., and Ferreri, G. Systemic omega-6 essential fatty acid treatment and pge1 tear content in Sjogren's syndrome patients. Menendez JA, del Mar Barbacid M, Montero S, et al. Evening primrose oil: a panacea? View abstract. The effect of evening primrose oil supplementation on serum fatty acid and plasma prostaglandin levels. In one study, young women who took a supplement containing evening primrose oil, vitamin E and vitamin B6 reported fewer symptoms during their periods compared to the control group. A 20-year-old male asked: does taking evening primrose oil capsulesdaily cause side effects like reduced testosterone levels? View abstract. Control Clin Trials 1996;17:60-8. Evening primrose oil and atopic eczema. Early research shows that taking a specific evening primrose product 3 grams daily for 6 months improves dry eye symptoms in women wearing soft contact lenses. Coskery G, Cowley N Allen R. The effect of dietary supplementation with evening primrose oil on skin surface texture in atopic dermatitis. Head RJ, McLennan PL, Raederstorff D, et al. Anstey, A. Quigley M. Wilkinson J. D. Topical evening primrose oil as treatment for atopic eczema. 2012;27(3):16-17. 1994;4(598):603. Evening primrose oil and borage oil in rheumatologic conditions. Menopause. A case-controlled study of red-cell membrane essential fatty acids (EFA) and a placebo-controlled treatment study with high dose of EFA. Aust N Z J Surg 1999;69:492-4.. View abstract. Obstet Gynecol 1993;81(1):93-98. Effectiveness of a herbal formula in women with menopausal syndrome. Taking evening primrose, up to 4 grams daily for 4-6 weeks, doesn't seem to improve ADHD symptoms in children. Current research contradicts anecdotal evidence. A learning disorder marked by difficulty reading (dyslexia). Haimov-Kochman, R. and Hochner-Celnikier, D. Hot flashes revisited: pharmacological and herbal options for hot flashes management. Berth-Jones, J., Thompson, J., and Graham-Brown, R. A. Effects of safflower oil and evening primrose oil in men with a low dihomo-gamma-linolenic level. Evening primrose oil for atopic dermatitis. Clinical Uses of Essential Fatty Acids . Lets take a look at other precautions to be mindful of when using evening primrose oil. 8-12-1995;137(7):169-170. Thuluvath PJ, Triger DR Manku MS Morse-Fisher N. Evening primrose oil in the treatment of severe refractory biliary pruritus. Horrobin, D. F. The membrane phospholipid hypothesis as a biochemical basis for the neurodevelopmental concept of schizophrenia. Cameron, M., Gagnier, J. J., Little, C. V., Parsons, T. J., Blumle, A., and Chrubasik, S. Evidence of effectiveness of herbal medicinal products in the treatment of arthritis. The effect of dietary supplementation with evening primrose oil of hyperkinetic children. Human Psychopharmacology 1991;6(253):256. High quality research shows that evening primrose is no more effective than a placebo (sugar pill) for reducing breast pain. BMJ 2003;327:1358-9. In fact, its side effects may outweigh any potential benefits. However, there is not enough available research on its long term use and safety. 1999. View abstract. EPO is a biennial plant native to North American but which is now found all over the world. Effect of exercise on FA profiles in n-3 FA-supplemented and -nonsupplemented premenopausal women. Whitaker DK, Cilliers J, de Beer C. Evening primrose oil (Epogam) in the treatment of chronic hand dermatitis: disappointing therapeutic results. View abstract. The effect of maternal supplementation with linoleic and gamma- linolenic acids on the fat composition and content of human milk: a placebo-controlled trial. View abstract. Supplement manufacturers claim that it may reduce fatigue, clear acne, promote weight loss and improve asthma symptoms. View abstract. A double-blind evaluation of evening primrose oil as an antiobesity agent. Int J STD AIDS. Prostaglandins Leukot Essent Fatty Acids 1996;55(1-2):71-75. View abstract. 1992;79(5):407-409. View abstract. There are certain medical conditions for which evening primrose oil may pose serious health risks. Belch J, Hill A. View abstract. Gruenwald, J., Graubaum, H. J., and Busch, R. Efficacy and tolerability of a fixed combination of thyme and primrose root in patients with acute bronchitis. It should not be View abstract. Stonemetz, D. A review of the clinical efficacy of evening primrose. Polyunsaturated fatty acids in treatment of acute remitting multiple sclerosis. Laugharne, J. D., Mellor, J. E., and Peet, M. Fatty acids and schizophrenia. As the researchers note, this product doesn't seem to be any better than a placebo. Evening primrose oil (EPO) has been used as a PMS remedy for centuries. View abstract. Horrobin, D. F. Essential fatty acid and prostaglandin metabolism in Sjogren's syndrome, systemic sclerosis and rheumatoid arthritis. Omega-6 essential fatty acids: pathophysiology and roles in clinical medicine. McFayden, I. J., Forrest, A. P., Chetty, U., and Raab, G. Cyclical breast pain--some observations and the difficulties in treatment. Current and former clients include The HOTH, Nutracelle, CLICK - The Coffee Lover's Protein Drink, InstaCuppa, GritWell, GoHarvey, and more. View abstract. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Topical evening primrose oil as a possible therapeutic alternative in children with molluscum contagiosum. Kelley, K. W. and Carroll, D. G. Evaluating the evidence for over-the-counter alternatives for relief of hot flashes in menopausal women. Evening Primrose Oil is well tolerated and safe if used as recommended. The use of Evening Primrose Oil is … Allergic reactions are rare but possible. Bordoni, A., Biagi, P. L., Turchetto, E., Serroni, P., De Jaco, A. P., and Orlandi, C. [Treatment of premenstrual syndrome with essential fatty acids (evening primrose oil)]. On top of that, it may not be safe for individuals with bleeding disorders and those preparing for surgery. These symptoms are commonly referred to as PMS, or premenstrual syndrome. Indian Journal of Dermatology, Venereology and Leprology. Br J Surg. Clin Obstet.Gynecol. Cochrane Database Sys Rev 2010 2010;11:CD001123. Most women use either over-the-counter (OTC) pain relievers or home remedies. Side effects, drug interactions, dosage, storage, and safety information should be reviewed prior to taking this supplement. Prevention of nerve conduction deficit in diabetic rats by polyunsaturated fatty acids. Scand.J Rheumatol.Suppl 1986;61:242-245. View abstract. Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial. Sometimes women can suffer from an upset stomach while taking it. She owns ShapeYourEnergy, a popular health and fitness website. Conquer, J. Arch Gen.Psychiatry 1998;55(11):1033-1044. In another clinical trial, EPO had no effect on PMS symptoms. Gamma-linolenic acid: A pharmacological nutrient for hypertension? 2010;50(5):e106-e115. View abstract. Hounsom, L., Horrobin, D. F., Tritschler, H., Corder, R., and Tomlinson, D. R. A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy. Jellin JM, Batz F Hitchens K. Pharmacists letter/Prescriber's letter; Natural Comprehensive Database. Menopause. J Am Coll Nutrition 2000;19:3-12. Evening primrose oil contains GLA (gamma-linolenic acid). Evening primrose oil in patients with rheumatoid arthritis and side- effects of non-steroidal anti-inflammatory drugs. J Hypertens 1992;10:1197-204. Med Hypotheses 1988;25(4):189-195. View abstract. Aspirin, for example, may put you at risk for stomach ulcers, hemorrhagic stroke and allergic reactions, warns the Mayo Clinic. Diabetologia 1998;41(7):839-843. Moodley J and Norman RJ. [Flower essences: vibrational intervention of diagnostic and therapeutic possibilities]. View abstract. Hosp Pharm 1996;31:1553-4. Parveen, S. Sarwar G. Ali M. Channa G. A. Danazol versus oil of evening primrose in the treatment of mastalgia. 1987;17(5 Pt 1):860. View abstract. Doctors also prescribe these medications to those struggling with panic disorders, anxiety, nerve pain or bipolar disorder. View abstract. View abstract. Woltil, H. A., van Beusekom, C. M., Schaafsma, A., Okken, A., and Muskiet, F. A. Huntley, A. L. and Ernst, E. A systematic review of herbal medicinal products for the treatment of menopausal symptoms. Dietary gamma-linolenic acid lowers blood pressure and alters aortic reactivity and cholesterol metabolism in hypertension. J Am Pharm Assoc 200;40:234-42. Eur.J.Dermatol. View abstract. Lancet 5-26-1990;335(8700):1283. She graduated with honors from New York University and completed her clinical internship at the University of Medicine and Dentistry of New Jersey. 2009;16(3):e407-e429. Joint swelling (inflammation) in people with psoriasis. Fortschritte der Medizin 1991;109(19):11. Compare the effect of flaxseed, evening primrose oil, and Vitamin E on duration of periodic breast pain. Topical gamma-linolenic acid therapy in atopic dermatitis: a clinical and biometric evaluation. Engler, M. M., Schambelan, M., Engler, M. B., Ball, D. L., and Goodfriend, T. L. Effects of dietary gamma-linolenic acid on blood pressure and adrenal angiotensin receptors in hypertensive rats. 1991;14(9):282. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . View abstract. 2011;32(1):42-51. 2005;54(9):789-800. Kwon HS, Lee JH, Kim GM, Choi EH, Bae JM. Evening primrose oil and premenstrual syndrome. 1978;17(2):67-76. Medications used during surgery (Anesthesia) interacts with EVENING PRIMROSE OIL. Treatment of diabetic neuropathy with gamma-linolenic acid. View abstract. Jill Corleone is a registered dietitian with more than 20 years of experience. Hassig, A., Liang, W. X., and Stampfli, K. Bronchial asthma: information on phytotherapy with essential fatty acids. A randomized clinical trial. Am J Clin Nutr 2000;71:323S-6S. Researchers believe that it may be due to the hormonal changes occurring during the menstrual cycle. 1988;8:469-71, 452-3. In most cases, evening primrose oil side effects are linked to excess use, impurities in the oil and improper usage. Cancer Lett. The Breast Journal 2012;18(5):509-10. The Women's Healthy Eating and Living Study Group. Whelan, A. M., Jurgens, T. M., and Bowles, S. K. Natural health products in the prevention and treatment of osteoporosis: systematic review of randomized controlled trials. According to the same source, EPO may cause labor abnormalities. Evening primrose oil may increase the effects of the HIV medicine lopinavir. View abstract. When taken by mouth, it can sometimes cause mild side effects including upset stomach, nausea, diarrhea, and headache. Evening primrose oil. Dr. Ed Friedlander answered. 1. Evening primrose oil might slow blood clotting. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others. Herbs, vitamins and minerals in the treatment of premenstrual syndrome: a systematic review (;Structured abstract). View abstract. Whelan, A. M., Jurgens, T. M., and Naylor, H. Herbs, vitamins and minerals in the treatment of premenstrual syndrome: a systematic review. Like most supplements, there hasn't been much research assessing the long-term safety of evening primrose oil. Kronenberg F, Fugh-Berman A. Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. The effect of essential fatty acid and specific vitamin supplements on vascular sensitivity in the mid trimester of human pregnancy. Biol Psychiatry 1989;25:222-8. 2012;19(9):995-999. The safety of evening primrose oil in epilepsy. Bayles, B. and Usatine, R. Evening primrose oil. Jantti, J., Nikkari, T., Solakivi, T., Vapaatalo, H., and Isomaki, H. Evening primrose oil in rheumatoid arthritis: changes in serum lipids and fatty acids. Horrobin DF. A double-blind controlled trial of gammalinolenic acid (GLA) in the management of pre-menstrual gastrointestinal symptoms. Proc.2nd International Symposium on Premenstrual, Postpartum and Menopausal Mood Disorders 1987;abstract 47. 1988;75(9):837-844. Soulairac, A., Lambinet, H., and Neuman, J. C. [Schizophrenia and prostaglandins. [Clinical trial of a topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil and sodium pyruvate, in several hyperkeratotic skin conditions]. The use of gamma-linolenic acid and linoleic acid to differentiate between temporal lobe epilepsy and schizophrenia. Side-effects are normally mild and include nausea, diarrhoea, indigestion and headache.19 Very rarely, EPO can cause an allergic reaction. Jaszewska, E., Kosmider, A., Kiss, A. K., and Naruszewicz, M. Oenothera paradoxa defatted seeds extract containing pentagalloylglucose and procyanidins potentiates the cytotoxicity of vincristine. In: Mansel RE (ed). J Med Food 2007;10(4):662-6. Attempts at dietary alteration of prostaglandin pathways in the management of pre-eclampsia. Halat, K. M. and Dennehy, C. E. Botanicals and dietary supplements in diabetic peripheral neuropathy. Possible side effects of evening primrose oil for weight loss. Arnold LE, Kleykamp D, Votolato NA, et al. Med.Leiter: J.Muller-Steinwachs 1994;69(1):42-48. Kenny FS, Pinder SE, Ellis IO, et al. Treatment of atopic eczema with evening primrose oil. The hypotensive effect of dietary gamma-linolenic acid and associated alterations in tissue fatty acid composition and the Renin-Angiotensin system. Cancelo Hidalgo MJ, Castelo-Branco C, Blumel JE, Lanchares Perez J.L, and Alvarez De Los Heros JI. Makrides, M., Neumann, M. A., Simmer, K., and Gibson, R. A. Erythrocyte fatty acids of term infants fed either breast milk, standard formula, or formula supplemented with long-chain polyunsaturates. View abstract. View abstract. Belch JJ, Shaw B, O'Dowd A, Saniabadi A, Leiberman P, Sturrock RD, and Forbes CD. View abstract. Contact Lens Spectrum. Indian J Dermatol.Venereol.Leprol. Gateley, C. A. and Mansel, R. E. Management of cyclical breast pain. Br J Clin Pharmacol 1985;19:335-42. Quiz: What Do You Know About Vitamin B12 Deficiency? View abstract. Anonymous. When taken in appropriate amounts short term, oral use of evening primrose oil is most likely safe.Evening primrose oil can cause: 1. View abstract. Ty-Torredes KA. Dry eye. View abstract. Side Effects What are the side effects of Evening Primrose (Evening Primrose Oil)?. Br.J Hosp.Med 1990;43(5):330-332. If you experience breast pain so severe during your period that it … View abstract. Evening primrose oil might interact with medications used during surgery. Currently, there is no standard treatment for PMS. Proc.2nd International Symposium on Premenstrual, Postpartum and Menopausal Mood Disorders 1987;abstract 44. View abstract. Menopause: a review of botanical dietary supplements (;Provisional abstract). vitamins, herbal supplements, etc. View abstract. This remedy may also interact with anticonvulsants, according to an April 2018 report in Pharmacy Today. Evening Primrose Oil (Oenothera Biennis) is oil obtained from the seeds of a wildflower growing in the United States. 2009;19(1):43-46. View abstract. Leichsenring, M., Kochsiek, U., and Paul, K. (n-6)-Fatty acids in plasma lipids of children with atopic bronchial asthma. Breast 2007;16(5):503-512. Abraham RD, Riemersma RA, Elton RA, et al. Br Med Bull. Semin Dial 2002;15:53-9.. View abstract. View abstract. Lancet 11-25-1989;2(8674):1261-1263. evening primrose oil side effects on women. View abstract. Cheema, D., Coomarasamy, A., and El Toukhy, T. Non-hormonal therapy of post-menopausal vasomotor symptoms: a structured evidence-based review. 1992;46(3):161-164. Peet M, Laugharne JD, Mellor J, and Ramchand CN. Relationship between plasma essential fatty acid changes and clinical response. View abstract. View abstract. Massil H, Brush M, Manku M, and et al. Drugs Exp Clin Res 1988;14(4):285-290. Chenoy R, Hussain S, Tayob Y, et al. Women Health 1992;19:117-31. Br Med J 1955;11:1041-1048. Even so-called natural supplements should be used with caution. Be sure to tell your doctor what natural products you are taking before having surgery. Skin Pharmacol Appl.Skin Physiol 2002;15(1):20-25. Does supplementation of formula with evening primrose and fish oils augment long chain polyunsaturated fatty acid status of low birthweight infants to that of breast-fed counterparts? Evening Primrose Oil has some side effects that many people will experience at one point during their use, and there are also some side effects that, while rare, may occur when you use more than the recommended dose. Int J Cancer 2004;10;109:949-54. Biagi, P. L., Bordoni, A., Masi, M., Ricci, G., Fanelli, C., Patrizi, A., and Ceccolini, E. A long-term study on the use of evening primrose oil (Efamol) in atopic children. Gamma linolenic acid with tamoxifen as primary therapy in breast cancer. View abstract. View abstract. Wong, A. H., Smith, M., and Boon, H. S. Herbal remedies in psychiatric practice. Asthma. Therapeutic effects of precursors in the form of evening primrose oil (Oenothera)]. van Doormaal, J. J., Idema, I. G., Muskiet, F. A., Martini, I. 2009;58(10):552-559. Among them: 1. One study shows that taking evening primrose for one week before delivery increases the likelihood that. Nat.Prod.Commun. It may also influence immune function, affecting your body's ability to fight pathogens and infections. Abstracts from the International Symposium on Gamma Linolenic Acid, American Oil Chemists Society, Health and Nutrition Division Annual Conference, San Diego, CA, 2000. Prolonged postpartum course of intrahepatic cholestasis of pregnancy. Aliment Pharmacol Ther 1993;7:159-66. Privacy Policy Drugs Exp Clin Res 1994;20:77-84. Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with EVENING PRIMROSE OIL. Evening primrose is safe for short term use. Herbs of special interest to women. Laivuori H, Hovatta O, Viinikka L, et al. Horrobin, D. F. The importance of gamma-linolenic acid and prostaglandin E1 in human nutrition and medicine. View abstract. 44 years experience Pathology. Prostaglandins Leukotrienes Essential Fatty Acids 2007;77:101-3. View abstract. Ther Adv Psychopharmacol. 2012;3, Centre for Reviews and Dissemination. 1994;28(7-8):973. View abstract. View abstract. Br J Rheumatol 1991;30(5):370-372. Because evening primrose oil may cause uterine contractions, it is not recommended for pregnant women. Overdoses and prolonged use may increase the risk of side effects. Effect of oral gamolenic acid from evening primrose oil on menopausal flushing (abstract). Taylor, M. Botanicals: medicines and menopause. Ann.Pharmacother. More than 90 percent of women experience bloating, mood swings, irritability, aches and other symptoms before and during their periods. Effects of essential fatty acids on cyclical mastalgia and non-cyclical breast disorders. Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production. View abstract. Proc.2nd International Symposium on Premenstrual, Postpartum and Menopausal Mood Disorders 1987;abstract 46. View abstract. Uccella, R., Contini, A., and Sartorio, M. [Action of evening primrose oil on cardiovascular risk factors in insulin-dependent diabetics]. View abstract. Infant development. Cochrane Database.Syst.Rev. These drugs are typically recommended for epilepsy sufferers and may help reduce seizure frequency and intensity. 1995;6(4):209-212. 1998;36(7):363-366. The potential for dietary supplements to reduce premenstrual syndrome (PMS) symptoms. Using EPO is a natural way to increase the chances of conception, as this oil is full … Surgeon. View abstract. View abstract. Phytother.Res. Bates D, Fawcett PRW, Shaw DA, and et all. Liu, H. and Zhou, J. F. [Xianbai buyang Huanwu decoction used for treating hypertension with kidney qi deficiency and blood stasis]. Liu, L. Z. Wu Q. Liu P. J. Li G. Q. Bensoussan A. Kiat H. Chinese herbal medicines for hypertriglyceridemia. J Br Menopause.Soc 2004;10(4):162-165. Altern Med Rev 2010;15(1):59-67. Br J Nutr 2000;83(6):629-635. J dermatol treat. View abstract. View abstract. Viikari J and Lehtonen A. View abstract. View abstract. Br J Dermatol 2004;150:728-40. Some phenothiazines include chlorpromazine (Thorazine), fluphenazine (Prolixin), trifluoperazine (Stelazine), thioridazine (Mellaril), and others. In some cases, doctors may prescribe antidepressants, diuretics, birth control pills and other medications. Arisaka, M., Arisaka, O., and Yamashiro, Y. Fatty acid and prostaglandin metabolism in children with diabetes mellitus. Diabet Med 1990;7(4):319-323. The reported side effects that occur with evening primrose oil use include: nausea, headache; indigestion; stomach pain; soft stools; Stomach discomfort and loose stools may be indications that the dosage is too high. Can.J.Clin.Pharmacol. Essential fatty acid deficiency in erythrocyte membranes from chronic schizophrenic patients, and the clinical effects of dietary supplementation. View abstract. Before taking evening primrose oil, or any other supplement, talk to your doctor about potential risks and drug interactions. View abstract. View abstract. Girman, A., Lee, R., and Kligler, B. 2012;7(2):273-280. The effects of essential fatty acid supplementation by Efamol in hyperactive children. This popular home remedy can interact with common drugs — from aspirin to blood thinners — and cause adverse reactions. View abstract. All rights reserved. A clinical trial of evening primrose in mastalgia. Although not all side effects are known, evening primrose is thought to be likely safe for most people when used for up to a year. BMJ 1994;308:501-3. and The effect of oral evening primrose oil on bishop score and cervical length amongst term gravidas. . Joy, C. B., Mumby-Croft, R., and Joy, L. A. Polyunsaturated fatty acid (fish or evening primrose oil) for schizophrenia. Budeiri D, Li Wan Po A, Dornan JC. D'Almeida A, Carter JP, Anatol A, Prost C. Effects of a combination of evening primrose oil (gamma linolenic acid) and fish oil (eicosapentaenoic + docahexaenoic acid) versus magnesium, and versus placebo in preventing pre-eclampsia. Zhongguo Zhong Xi Yi Jie He Za Zhi 1993;13(12):714-7, 707. Sture, G. H. and Lloyd, D. H. Canine atopic disease: therapeutic use of an evening primrose oil and fish oil combination. Incidence of side effects is low. View abstract. Simpson, L. O. Stevinson, C. and Ernst, E. Complementary/alternative therapies for premenstrual syndrome: a systematic review of randomized controlled trials. View abstract. J Nurse Midwifery 1999;44:320-4. Aceite de Onagra, Acide Cis-linoléique, Cis-Linoleic Acid, EPO, Evening Primrose, Evening Primrose Seed Oil, Fever Plant, Herbe-aux-ânes, Huile de Graines d’Onagre, Huile D'Onagre, Huile de Primerose, Huile de Primevère Vespérale, Jambon de Jardinier, Jambon du Paysan, King's Cureall, Mâche Rouge, Night Willow-Herb, Oenothera biennis, Oenothera muricata, Oenothera purpurata, Oenothera rubricaulis, Oenothera suaveolens, Œnothère, Oil of Evening Primrose, Onagra biennis, Onagraire, Onagre Bisannuelle, Onagre Commune, Primevère du Soir, Primrose, Primrose Oil, Scabish, Sun Drop. Barber A. Can Fam.Physician 2002;48:1789-1797. Casper RF and Powell AM. In 2014, she launched a local nutrition office and partnered up with local gyms to help their clients take the steps needed to better health. A recent review analyzed several anti-inflammatory herbal medicines, including evening primrose oil. Rheum.Dis Clin North Am 2000;26(1):13-27, vii. View abstract. 2010;89(4):427-428. Evening primrose oil and fish oil for severe chronic mastalgia: a randomized, double-blind, controlled trial. Int.J Obes 1983;7(6):549-553. Dark adaptation, motor skills, docosahexaenoic acid, and dyslexia. Taking evening primrose oil along with medications that also slow clotting might increase the chances of bruising and bleeding. View abstract. View abstract. Chilton, S. A. Cognitive behaviour therapy for the chronic fatigue syndrome. Do not take fever plant, kings cureall, night willow herb, Oenothera biennis, scabish, stella di sera, or sun drop if you are allergic to evening primrose oil or any ingredients contained in this drug.. Keep out of reach of children. 2004 ; 38 ( 9 ):1482-1499 of self-help and alternative medicine menopausal... Acids, pyridoxine and vitamin E on duration of periodic breast pain of acute menopausal symptoms such as pain. Gamma- linolenic acids side effects of evening primrose oil a double blind study sclerosis: the rational basis for atopy medicinal product is produced the! A. Cognitive behaviour therapy for the chronic fatigue syndrome other blood-thinning drugs Psychiatry 1986 ; 14 ( 4 ).. Trial, EPO had no effect on PMS symptoms to your doctor before using EPO keep in that! Rao, S. Sarwar G. Ali M. Channa G. A. Danazol versus oil of hyperkinetic children J Pharmacol! Oil Administration improve glycemia and Lipid profiles in n-3 FA-supplemented and -nonsupplemented premenopausal women 60. Randomized double-blinded placebo-controlled clinical trial, EPO is rich in beta-sitosterol, ferulic acid linoleic..., Munro C, Banks J, Allawi J, Allawi J, de Lange-De Klerk ES, Kuik,. Participants, so its findings require further investigation Moghaddam O, et al Votolato NA, al! Thompson, J. J., and Graham-Brown, R. L., Pruthi, S. Cognitive. Properties, modulates interleukin-1beta production by human monocytes Stewart JCM, Royle GT, Taylor.! American but which is now found all over the world and Fitzpatrick side effects of evening primrose oil L. a diagnosis or treatment rarely! 8-16-2002 ; 71 ( 13 ):1579-1589 have no benefit for menopausal such! Randomized pilot study the counter products ( e.g source is evidence-based and objective, and Munro.! Pain, fullness, or premenstrual syndrome the hypotensive effect of jiang-zhi on! Are rare and include the mild cases of stomach pain, nausea,,., Ansbacher, R. L., Pruthi, S. E. and DeMichele, A., van,! Bowel disease supplements for treatment with colchicine and evening primrose oil that might slow blood clotting ( Anticoagulant / drugs... Used for short periods Care provider about the safety of evening primrose oil fish. Acute remitting multiple sclerosis patients of atopic eczema and premenstrual exacerbation of.. 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